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Israeli Firm Starts Testing Psychedelic Nasal Spray as PTSD Treatment

The next few decades will likely see psychedelic treatments go from relative obscurity to playing center stage in the psychiatric space. After decades of prohibition, psychedelics are now emerging as a potential alternative to traditional mental health therapies amid a surge in psychedelic research.

Numerous studies have revealed that hallucinogenic drugs can deliver significant mental health benefits when paired with talk therapy. Psychedelics may finally allow people to gain long-term relief from conditions such as post-traumatic stress disorder and depression, which often fail to respond to conventional treatments.

Although a lot of psychedelic research has occurred in Western countries such as the United States, Canada and Australia, other nations aren’t being left behind. In the Middle East, an Israeli startup plans to begin testing a new psychedelic spray to treat PTSD. Over the last two years, the Israeli Defense Ministry has identified that at least 5,000 Israelis suffer from post-traumatic stress disorder. The mental health disorder tends to affect women more than men, and is especially prevalent among soldiers who see active combat.

Existing therapies for PTSD aren’t always effective, and they don’t work for everyone, necessitating the development of more efficient PTSD treatments. The recent surge in psychedelic research has revealed that hallucinogenics have plenty of potential as therapies for PTSD, especially when paired with psychotherapy.

Madrigal Mental Care Facility chief of the advisory board, clinical psychologist and PTSD specialist Or Doek explains that there is no treatment for the underlying cause of PTSD and current treatments, such as antidepressants, are just meant to alleviate the symptoms.

Psychedelics are becoming increasingly popular as they offer patients a chance to deal with the underlying trauma and traumatic memories that cause disruptive mental health symptoms. Doek says that psychedelics help patients reframe traumatic memories from traumatic events to sad events and remove their negative power.

Madrigal Mental Care Facility founder David Gabbay developed technology that facilitates the delivery of hallucinogenics into the brain in minute doses. He explains that the technology encloses a psychedelic molecule in a nanobiodegradable capsule, which is then suspended in a nasal spray. The minuscule dose and the quick-delivery system cause immediate effects without the “psychedelic trip,” allowing patients to reframe prior traumatic events without experiencing hallucinogenic effects.

According to Gabbay, Madrigal Mental Care Facility is researching the effects of psilocybin, ketamine and ecstasy on the brain. The facility expects to begin human trials of its psychedelic nasal spray by 2024.

With all the investment being injected into psychedelic research and product development by companies such as Mind Medicine Inc. (NASDAQ: MNMD) (NEO: MMED) (DE: MMQ), it may not be long before different formulations are approved for use via various administration methods tailored for different groups of patients.

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